Publications.

Gabrielle Grifno, Han Ali Kahvecioglu, Victoria Travnik, Robert LeBourdais, Rohin Banerji, Winita Wangsrikhun, Linzheng Shi, Suleyman B. Bozal, Heewon Suh, Athanasios Batgidis, Abdulrahman Kobayter, Lauren Castle, Kathryn Regan, Feiyang Deng, Michael Vannini, Mohammad Rashidian, Liang Hao, Joseph P. Mizgerd, Worth Longest, Michael Hindle, W. Mark Saltzman, James P. Butler, Béla Suki, H. T. Nia.

Real-time single-particle imaging of functional lungs reveals mosaic-like patterns of aerosol deposition in alveoli

Nature Biomedical Engineering · 2026

Gabrielle Grifno and Hadi T. Nia.

Single-particle imaging reveals lung functional heterogeneity in alveoli

Nature Biomedical Engineering · 2026

Hall, J.K., Deng, Y., Kontodimas, K. Nia, H., Varelas, X., Lutchen, K., Bates, J., Suki, B.

A large-scale balloon model of confluent cells validates stress inference from geometry

npj Biol. Phys. Mech. 3, 1 · 2026

Yuqing Deng, Byungjun Kang, Linzheng Shi, Chanhong Min, Kathryn Regan, Joseph K Hall, Abdulrahman Kobayter, Neel Sajja, Kenneth R Lutchen, J William Boley, Jude M Phillip, Béla Suki, Hadi T Nia.

Neutrophil migration in the lung is altered by alveolar collapse and stretch

bioRxiv · 2026 · Preprint

Kathryn Regan, Lauren Castle, Robert LeBourdais, Abdulrahman Kobayter, Linzheng Shi, Winita Wangsrikhun, Gabrielle Grifno, Rohin Banerji, Athanasios Batgidis, Bela Suki, Hadi T. Nia.

Micromechanics of lung capillaries across mouse lifespan and in positive vs negative-pressure ventilation

npj Biological Physics and Mechanics · 2025

H. T. Nia, L. L. Munn, R. K. Jain.

Probing the physical hallmarks of cancer

Nature Methods · 2025

Muhamed Hadzipasic, Margaret S. Sten, Elie Massaad, Ali Kiapour, George Nageeb, Muneeb A. Sharif Joseph Bradley, Gunnlaugur P. Nielsen, Jean-Valery C. Coumans, Lawrence F. Borges, John H. Shin, Alan J. Grodzinsky, Hadi T. Nia, and Ganesh M. Shankar.

ROCK-dependent mechanotransduction of macroscale forces drives fibrosis in degenerative spinal disease

Nature Biomedical Engineering · 2025

Taha Rakhshandehroo, Shreya R. Mantri, Heydar Moravej, Benjamin Louis, Ali Salehi Farid, Leila Munaretto, Kathryn Regan, Min Cong, Adrien Kuhnast, Ali Nili, Harris Allen, Lea Berland, Ester Simkova, Safak Uslu, Jessika Baral, Soheil Tavakolpour, Jennifer Rowley, Haneyeh Shahbazian, Jason Pyrdol, Caron Jacobson, Omar Nadeem, Hadi Nia, Kai Wucherpfennig, Mohammad Rashidian.

A CAR enhancer increases the activity and persistence of CAR T cells

Nature Biotechnology · 2024

Etesami NS, Barker KA, Shenoy AT, De Ana CL, Arafa EI, Grifno GN, Matschulat AM, Vannini ME, Pihl RMF, Breen MP, Soucy AM, Goltry WN, Ha CT, Betsuyaku H, Browning JL, Varelas X, Traber KE, Jones MR, Quinton LJ, Maglione PJ, Nia HT, Belkina AC and Mizgerd JP.

B cells in the pneumococcus-infected lung are heterogeneous and require CD4+ T cell help including CD40L to become resident memory B cells

Front. Immunology · 2024

LeBourdais Robert, Gabrielle N Grifno, Rohin Banerji, Kathryn Regan, Bela Suki, Hadi T. Nia.

Mapping the strain-stiffening behavior of the lung and lung cancer at microscale resolution using the crystal ribcage

Frontiers in Network Physiology · 2024

Kathryn Regan, Robert LeBourdais, Rohin Banerji, Johnathan Muhvich, Siyi Zheng, Sue Zhang, Hadi T. Nia.

Multiscale elasticity mapping of biological samples in 3D at optical resolution

Acta Biomaterialia · 2024

Muhamed Hadzipasic, Sue Zhang, Zhuoying Huang, Rachel Passaro, Margaret Sten, Ganesh Shankar, Hadi T. Nia.

Emergence of nanoscale viscoelasticity from single cancer cells to established tumors

Biomaterials · 2024

Siyi Zheng, Rohin Banerji, Rob LeBourdais, Sue Zhang, Eric DuBois, Timothy O’Shea, Hadi T. Nia.

Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke

PNAS Nexus · 2024

Rohin Banerji,, Gabrielle N. Grifno,, Linzheng Shi, Dylan Smolen, Rob LeBourdais, Johnathan Muhvich, Cate Eberman, Bradley Hiller, Jisu Lee, Kathryn Regan, Siyi Zheng, Sue S. Zhang, John Jiang, Riley Phil, Katrina Traber, Giovanni Ligresti, Joseph P. Mizgerd, Bela Suki, Hadi T. Nia.

Crystal ribcage: a platform for probing real-time lung function at cellular resolution

Nature Methods · 2023

Sue Zhang, Rachel Passaro, Kathryn Regan, Muhamed Hadzipasic, Gabrielle Grifno, Siyi Zheng, Logan O'Connor, Vinson Chu, Sung Yeon Kim, Jiarui Yang, Rohin Banerji, Kavon Karrobi, Darren Roblyer, Mark Grinstaff, Hadi T. Nia.

Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission

Nature Biomedical Engineering · 2023

Sue Zhang, Kathryn Regan, Julian Najera, Mark W. Grinstaff, Meenal Datta, Hadi T. Nia.

The peritumor microenvironment: physics and immunity

Trends in Cancer · 2023

Elizabeth L. Doherty, Wen Yih Aw, Emily C. Warren, Max Hockenberry, Chloe P. Whitworth, Grace Krohn, Stefanie Howell, Brian O. Diekman, Wesley R. Legant, Hadi T. Nia, Anthony J. Hickey, William J. Polacheck.

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics

Acta Biomaterialia · 2023

Linzheng Shi, Jacob Herman, Samer Bou Jawde, Jason HT Bates, Hadi T. Nia; Béla Suki.

Modeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure–volume curves

Scientific Reports, 12 (1), pp. 1-12 · 2022

Z. Yuan, J. H., S. Murthy, K. Peters, H. T. Nia, K. R. Lutchen and B. Suki.

A Personalized Spring Network Representation of Emphysematous Lungs From CT Images

Frontiers In Network Physiology · 2022

S. Aoki, K. Inoue, S. Klein, S. Halvorsen, J. Chen, A. Matsui, M. Nikmaneshi, S. Kitahara, T. Hato, X. Chen, K. Kawakubo, H. T. Nia, I. Chen, D. H Schanne, E. Mamessier, K. Shigeta, H. Kikuchi, R. Ramjiawan, T. CE Schmidt, M. Iwasaki, T. Yau, T. Hong, A. Quaas, P. S Plum, S. Dima, I. Popescu, N. Bardeesy, L. L Munn, M. J Borad, S. Sassi, R. K Jain, A. X Zhu, D. G Duda.

Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma

Gut, 71(1), 185-193 · 2022

D. Jones, Z. Wang, I. X. Chen, S. Zhang, R. Banerji, P. Lei, H. Zhou, V. Xiao, C. Kwong, J. W. M. van Wijnbergen, E. R. Pereira, B. J. Vakoc, P. Huang, H. T. Nia, and T. P. Padera.

Solid stress impairs lymphocyte infiltration into lymph-node metastases

Nature Biomedical Engineering, 1-11 · 2021

H.T. Nia, L.L. Munn and R.K. Jain.

Physical traits of cancer

Science, 370, eaaz0868 · 2020

H.T. Nia, M. Datta, G. Seano, S. Zhang, W.W. Ho, S. Roberge, P. Huang, L.L. Munn and R.K. Jain.

In vivo compression and imaging in mouse brain to measure the effects of solid stress

Nature Protocols · 2020

L. Munn and H. T. Nia.

Mechanosensing tensile solid stresses

PNAS, 116 (44), 21960-21962 · 2019

H. T. Nia, L. Munn, and R. K. Jain.

Mapping physical tumor microenvironment and drug delivery

Clinical Cancer Research · 2019

J. B. Sellon, M. Azadi, R. Oftadeh, H. T. Nia, R. Ghaffari, A. J. Grodzinsky, and D. M. Freeman.

Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections

Physical Review Letters, 122, 028101 · 2019

G. Seano, H. T. Nia, K. Emblem, M. Datta, J. Ren, J. Kloepper, S. Krishnan, M. Ghosh, M. Pinho, V. Askoxylakis, G. Ferraro, L. Riedemann, E.Gerstner, T. Batchelor, P. Wen, N. Lin, A. Grodzinsky, D. Fukumura, P. Huang, J. Baish, T. Padera, L. Munn, R.K. Jain.

Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium

Nature Biomedical Engineering, 3, 230–245 · 2019

Y. Zhao, J. Cao, A. Melamed, M. Worley, A. Gockley, D. Jones, H. T. Nia, Y. Zhang, T. Stylianopoulos, A. Kumar, F. Mpekris, M. Datta, Y. Sun, L. Wu, X. Gao, O. Yeku, M. del Carmen, D. Spriggs, R. K. Jain, L. Xu.

Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma

PNAS, 116 (6) 2210-2219 · 2019

H. T. Nia, M. Datta, G. Seano, P. Huang, L. Munn, and R.K. Jain.

Quantifying solid stress and elastic energy from excised or in situ tumors

Nature Protocols, 13(5), 1091. *: equal contribution · 2018

R Oftadeh, B. Connizzo, H. T. Nia, C. Ortiz, A. Grodzinsky.

Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: application to tendon and skin biophysics

Acta Biomaterialia, 70, 249-259 · 2018

H. T. Nia, H. Liu, G. Seano, M. Datta, D. Jones, N. Rahbari, J. Incio, V. P. Chauhan, K. Jung, J. D. Martin, V. Askoxylakis, T. P. Padera, D. Fukumura, Y. Boucher, F. J. Hornicek, A. J. Grodzinsky, J. W. Baish, L. Munn, and R.K. Jain.

Solid stress and elastic energy as measures of tumour mechanopathology

Nature Biomedical Engineering 1, 0004 · 2017

B. Han, H. T. Nia, C. Wang, O. Chandrasekaran, Q. Li, D. Chery, H. Li A. J. Grodzinsky, and L. Han.

AFM-nanomechanical test: an interdisciplinary tool that links the understanding of cartilage and meniscus biomechanics, osteoarthritis degeneration, and tissue engineering

ACS Biomater. Sci. Eng., 3 (9), 2033-2049 · 2017

J. Incio, P.Suboj, S.M. Chin, Y. Huang, H. T. Nia, S. Kao, S. Babykutty, N. Rahbari, V. Chauhan, J. Martin, R. Ngo, I. Chen, H. Liu, X. Han, T. Reiberger, J. Gravohac, K. Jung, P. Huang, R. Soares, Y. Boucher, D. Fukumura, R.K. Jain.

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy

Cancer Discovery, 6 (8), 852-869 · 2016

N. Rahbari, D. Kedrin, J. Incio, T. Reiberger, H. Liu, H. T. Nia, C. Edrich, J. Dubroix, I. Chen, T. Heishi, J. Martin, Y. Huang, A. J. Grodzinsky, D. G. Duda, R. K. Jain & D. Fukumura.

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

Science Translational Medicine, 8 (360) · 2016

Z. Hajjarian, H. T. Nia, S. Ahn, A. J. Grodzinsky, R. K. Jain, and S. K. Nadkarni.

Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds

Scientific Report, 6 · 2016

M. Azadi, H. T. Nia, S. Gauci, A. Fosang, C. Ortiz and A. Grodzinsky.

Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse

Journal of Biomechanics, 49 (9), 1634–1640. *: equal contribution · 2016

H. T. Nia, L. Han, I. Soltani, P. Roughley, K. Youcef-Toumi, A. Grodzinsky and C. Ortiz.

Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties

ACS Nano, 9 (3), 2614-2625 · 2015

G. Scarcelli, W. Polacheck, H. T. Nia, K. Patel, A. J. Grodzinsky, R. Kamm and SH Yun.

Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy

Nature Methods, 12 (12), 1132-1134 · 2015

H. T. Nia, S. Gauci, M. Azadi, H. Hung, E. Frank, A. Fosang, C. Ortiz and A. J. Grodzinsky.

High-bandwidth AFM-based rheology is a sensitive indicator of early cartilage aggrecan degradation relevant to mouse models of osteoarthritis

Journal of Biomechanics, 48, pp. 162-168 · 2015

H. T. Nia, A. Jain, M. Alam, Y. Liu, R. Barnas, and N.C. Makris.

The evolution of air resonance power efficiency in the violin and its ancestors

Royal Society Proceeding A · 2015

M. A. Batista, H. T. Nia, P. Önnerfjord, K. A. Cox, C. Ortiz, A. J. Grodzinsky, D. Heinegård and L. Han.

Nanomechanical phenotype of chondroadherin-null murine articular cartilage

Matrix Biology, 38, pp. 84-90 · 2014

H. T. Nia, I. Soltani, Y. Li, L. Han, H. Hung, E. Frank, K. Youcef-Toumi, C. Ortiz and A. Grodzinsky.

High bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment

Biophysical Journal, 104(7) pp. 1529-1537 · 2013

D. J. Rubin, H. T. Nia, T. Desire, P. Nguyen, M. Gevelber, C. Ortiz and N. Joshi.

Mechanical reinforcement of polymeric fibers through peptide nanotube incorporation

Biomacromolecules, 14(10) pp 3370–3375 · 2013

H. T. Nia, L. Han, Y. Li, C. Ortiz and A. J. Grodzinsky.

Poroelasticity of cartilage at the nanoscale

Biophysical Journal, 101(9) pp. 2304-2313 · 2011

S. Jagannathan, D. Symonds, I. Bertsatos, T. Chen, M. Andrews, Z. Gong, N. Donabed, H. T. Nia, A. Tan, L. Ngor, R. Nero, M. Jech, O. R. Godo, S. Lee, P. Ratilal, and N. Makris.

Ocean Acoustic Waveguide Remote Sensing (OAWRS) of marine ecosystems

Marine Ecology Progress Series, 395, pp. 137-160 · 2009

K. Sugimoto, and H. T. Nia.

Dynamic Simulator of Mechanisms Based on the Tangent and Cotangent Vectors

Journal of Robotic Society of Japan, 25(4), pp. 134-140 (In Japanese) · 2007

H. T. Nia, H. N. Pishkenari and A. Meghdari.

A recursive approach for the analysis of snake robots using Kane’s equations

Robotica, 24(2), pp. 251-256 · 2006

H. T. Nia and R. Hatakenaka.

The two top universities in Iran and Japan, a Brief Comparison

The Japan Society of Mechanical Engineers Magazine, 108, pp. 964-5 (In Japanese) · 2005

H. Zohoor and H. T. Nia.

Optimal synthesis of planar and spatial mechanisms for path generation using regression deviation

Scientica Iranica, 12(2), pp. 190-198 · 2005

Linzheng Shi, Michael Vannini, Lauren Castle, Andrew Tsao, Abdulrahman Kobayter, Chanhong Min, Athanasios Batgidis, Kathryn Regan, Rohin Banerji, Gabrielle Grifno, Yuqing Deng, Robert LeBourdais, Jessica Daher, Byungjun Kang, Winita Wangsrikhun, Han Kahvecioglu, Catherine T. Ha, Elise M.R. Armstrong, Bradley E. Hiller, Erin Crossey, John Jiang, Mohammad Rashidian, Béla Suki, Jude M. Phillip, Joseph P. Mizgerd, Hadi T. Nia.

Lung-resident immunity governs early pneumonia defense revealed by the paracorporeal crystal ribcage

Under review