R. LeBourdais, G. N. Grifno, R. Banerji, K. Regan, B. Suki, H. T. Nia, “Mapping the strain-stiffening behavior of the lung and lung cancer at microscale resolution using the crystal ribcage”, Frontiers in Network Physiology, Vol. 4, 2024.
https://doi.org/10.3389/fnetp.2024.1396593
M. Hadzipasic, S. Zhang, Z. Huang, R. Passaro, M. S. Sten, G. M. Shankar, H. T. Nia, “Emergence of nanoscale viscoelasticity from single cancer cells to established tumors”, Biomaterials, Vol. 305, 122431, 2024.
https://doi.org/10.1016/j.biomaterials.2023.122431
K. Regan, R. LeBourdais, R. Banerji, S. Zhang, J. Muhvich, S. Zheng, H. T. Nia, “Multiscale elasticity mapping of biological samples in 3D at optical resolution”, Acta Biomaterialia, 2024.
https://doi.org/10.1016/j.actbio.2023.12.036
S. Zheng, R. Banerji, R. LeBourdais, S. Zhang, E. DuBois, T. O’Shea, H. T. Nia, “Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke”, PNAS Nexus, Vol. 3, Issue 4, page 141, 2024.
https://doi.org/10.1093/pnasnexus/pgae141
N. S. Etesami, K. A. Barker, A. T. Shenoy, C. Lyon De Ana, E. I. Arafa, G. N. Grifno, A. M. Matschulat, M. E. Vannini, R. M. F. Pihl, M. P. Breen, A. M. Soucy, W. N. Goltry, C. T. Ha, H. Betsuyaku, J. L. Browning, X. Varelas, K. E. Traber, M. R. Jones, L. J. Quinton, P. J. Maglione, H. T. Nia, A. C. Belkina, J. P. Mizgerd, “B cells in the pneumococcus-infected lung are heterogeneous and require CD4+ T cell help including CD40L to become resident memory B cells”, Frontiers in Immunology, Vol. 15, 2024.
https://doi.org/10.3389/fimmu.2024.1382638
T. Rakhshandehroo, S. R. Mantri, H. Moravej, B. B. V. Louis, A. Salehi Farid, L. Munaretto, K. Regan, R. M. M. Khan, A. Wolff, Z. Farkash, M. Cong, A. Kuhnast, A. Nili, U. Lee, H. H. Allen, L. Berland, E. Simkova, S. C. Uslu, S. Tavakolpour, J. E. Rowley, E. Codet, H. Shahbazian, J. Baral, J. Pyrdol, C. A. Jacobson, O. Nadeem, H. T. Nia, K. W. Wucherpfennig, M. Rashidian, “A CAR enhancer increases the activity and persistence of CAR T cells”, Nature Biotechnology, 2024.
https://doi.org/10.1038/s41587-024-02339-4
Sue Zhang*, Kathryn Regan*, Julian Najera, Mark W. Grinstaff, Meenal Datta, Hadi T. Nia, “The peritumor microenvironment: physics and immunity”, Trends in Cancer, In press 2023.
Nia, Hadi; et al. 2022. OPTICALLY TRANSPARENT RIBCAGE AND USES THEREOF. Provisional Patent
Nia, Hadi; et al. 2022. 3D ELASTICITY MAPPING OF BIOLOGICAL SAMPLES. 63/409,295. Filed September 23, 2022. Provisional Patent
S. Aoki, K. Inoue, S. Klein, S. Halvorsen, J. Chen, A. Matsui, M. R. Nikmaneshi, S. Kitahara, T. Hato, X. Chen, K. Kawakubo, H. T. Nia, I. Chen, D. H. Schanne, E. Mamessier, K. Shigeta, H. Kikuchi, R. R. Ramjiawan, T. C.E. Schmidt,
M. Iwasaki, T. Yau, T. S. Hong, A. Quaas, P. S. Plum, S. Dima, I. Popescu, N. Bardeesy, L. L. Munn, M. J. Borad, S. Sassi, R. K. Jain, A. X. Zhu, D. G. Duda, “Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma”. Gut 2022;71:185-193.
DOI: 10.1136/gutjnl-2020-322493
Z. Yuan, J. Herrmann, S. Murthy, K. Peters, S.E. Gerard, H. T. Nia, K.R. Lutchen, B. Suki, “A Personalized Spring Network Representation of Emphysematous Lungs From CT Images”. Front. Netw. Physiol. 2022. 2:828157.
DOI: 10.3389/fnetp.2022.828157
L. Shi, J. Herrmann, S. Bou Jawde, J. H.T. Bates, H. T. Nia, B. Suki, “Modeling the influence of gravity and the mechanical properties of elastin and collagen fibers on alveolar and lung pressure–volume curves”. Sci Rep 2022. 12, 12280.
DOI: 10.1038/s41598-022-16650-0
Jones, Z. Wang, I. X. Chen, S. Zhang, R. Banerji, P. Lei, H. Zhou, V. Xiao, C. Kwong, J. W. M. van Wijnbergen, E. R. Pereira, B. J. Vakoc, P. Huang, H. T. Nia, and T. P. Padera, “Solid stress impairs lymphocyte infiltration into lymph-node metastases”, Nature Biomedical Engineering, 2021.
DOI 10.1038/s41551-021-00766-1
H.T. Nia, , L.L. Munn and R.K. Jain, “Physical traits of cancer”, Science, 370, eaaz0868 (2020), DOI: 10.1126/science.aaz0868.
H.T. Nia, M. Datta, G. Seano, S. Zhang, W.W. Ho, S. Roberge, P. Huang, L.L. Munn and R.K. Jain, “In vivo compression and imaging in mouse brain to measure the effects of solid stress”, Nature Protocols, 2020, https://doi.org/10.1038/s41596-020-0328-2, Behind the paper
L. L. Munn and H. T. Nia, “Mechanosensing tensile solid stresses” Proceedings of National Academy of Sciences, 21960-21962, 2019
H. T. Nia, L.L. Munn, and R.K. Jain, “Mapping physical tumor microenvironment and drug delivery,” Clinical Cancer Research, 2019, DOI: 10.1158/1078-0432.CCR-18-3724
G. Seano*, H. T. Nia*, K. Emblem*, M. Datta, J. Ren, J. Kloepper, S. Krishnan, M. Ghosh, M. Pinho, V. Askoxylakis, G. Ferraro, L. Riedemann, E.Gerstner, T. Batchelor, P. Wen, N. Lin, A. Grodzinsky, D. Fukumura, P. Huang, J. Baish, T. Padera, L. Munn, R.K. Jain, “Neurological dysfunction induced by brain tumor-generated solid stress is reversed by lithium treatment,” Nature Biomedical Engineering, 3, 230–245, 2019 *: equal contribution. News and Views, Trends in Cancer Spotlight
Y. Zhao, J. Cao, A. Melamed, M. Worley, A. Gockley, D. Jones, H. T. Nia, Y. Zhang, T. Stylianopoulos, A. S. Kumar, F. Mpekris, M. Datta, Y. Sun, L. W., X. Gao, O. Yeku, M. G. del Carmen, D. R. Spriggs, R. K. Jain, and L. Xu, “Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma,” PNAS, 116 (6) 2210-2219, 2019
B. Sellon, M. Azadi, R. Oftadeh, H. T. Nia, R. Ghaffari, A. J. Grodzinsky, and D. M. Freeman, “Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections,” Physical Review Letters, 122, 028101, 2019; MIT News
H. T. Nia, H. Liu, G. Seano, M. Datta, D. Jones, N. Rahbari, J. Incio, V. P. Chauhan, K. Jung, J. D. Martin, V. Askoxylakis, T. P. Padera, D. Fukumura, Y. Boucher, F. J. Hornicek, A. J. Grodzinsky, J. W. Baish, L. Munn, and R.K. Jain, “Solid stress and elastic energy as measures of tumour mechanopathology,” Nature Biomedical Engineering 1, 0004, 2017. Featured by News and Views, Nature Reviews Clinical Oncology, HMS News, EurekaAlert, Behind the paper
H. T. Nia*, M. Datta*, G. Seano, P. Huang, L. Munn, and R.K. Jain, “Quantifying solid stress and elastic energy from excised or in situ tumors,” Nature Protocols, 13(5), 1091, 2018. *: equal contribution.
R Oftadeh, B. Connizzo, H. T. Nia, C. Ortiz, A. Grodzinsky, “Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: application to tendon and skin biophysics,” Acta Biomaterialia, 70, 249-259, 2018.
J. Incio, P.Suboj, S.M. Chin, Y. Huang, H. T. Nia, S. Kao, S. Babykutty, N. Rahbari, V. Chauhan, J. Martin, R. Ngo, I. Chen, H. Liu, X. Han, T. Reiberger, J. Gravohac, K. Jung, P. Huang, R. Soares, Y. Boucher, D. Fukumura, R.K. Jain, “Obesity-induced inflammation aggravates desmoplasia in PDAC reducing the efficacy of chemotherapy,”, Cancer Discovery, 6 (8), 852-869, 2016. Featured by Nature News and Views, Science Signaling
N. Rahbari, D. Kedrin, J. Incio, T. Reiberger, H. Liu, H. T. Nia, C. Edrich, J. Dubroix, I. Chen, T. Heishi, J. Martin, Y. Huang, A. J. Grodzinsky, D. G. Duda, R. K. Jain & D. Fukumura, “Extracellular matrix remodeling after anti-VEGF therapy contributes to therapeutic resistance in colorectal cancer liver metastases,” Science Translational Medicine, 8 (360), 2016. Featured by Nature Reviews Gastroenterology & Hepatology
B. Han, H. T. Nia, C. Wang, O. Chandrasekaran, Q. Li, D. Chery, H. Li A. J. Grodzinsky, and L. Han, “AFM-nanomechanical test: an interdisciplinary tool that links the understanding of cartilage and meniscus biomechanics, osteoarthritis degeneration, and tissue engineering,” ACS Biomater. Sci. Eng., 3 (9), 2033-2049, 2017.
Z. Hajjarian, H. T. Nia, S. Ahn, A. J. Grodzinsky, R. K. Jain, and S. K. Nadkarni, “Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds,” Scientific Report, 6, 2016
H. T. Nia, L. Han, I. Soltani, P. Roughley, K. Youcef-Toumi, A. Grodzinsky and C. Ortiz, “Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties,” ACS Nano, 9 (3), 2614-2625, 2015
M. Azadi*, H. T. Nia*, S. Gauci, A. Fosang, C. Ortiz and A. Grodzinsky, “Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse,” Journal of Biomechanics, 49 (9), 1634–1640, 2016. *: equal contribution
H. T. Nia, I. Soltani, Y. Li, L. Han, H. Hung, E. Frank, K. Youcef-Toumi, C. Ortiz and A. Grodzinsky, “High bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment,” Biophysical Journal, 104(7) pp. 1529-1537, 2013. Featured by: MIT News, Sciencedaily
G. Scarcelli, W. Polacheck, H. T. Nia, K. Patel, A. J. Grodzinsky, R. Kamm and SH Yun, “Noncontact mapping of intracellular hydromechanical properties by Brillouin confocal microscopy,” Nature Methods, 12 (12), 1132-1134, 2015. Featured by: REUTERS, Yahoo News
H. T. Nia, S. Gauci, M. Azadi, H. Hung, E. Frank, A. Fosang, C. Ortiz and A. J. Grodzinsky, “High-bandwidth AFM-based rheology is a sensitive indicator of early cartilage aggrecan degradation relevant to mouse models of osteoarthritis,” Journal of Biomechanics, 48, pp. 162-168, 2015
M. A. Batista, H. T. Nia, P. Önnerfjord, K. A. Cox, C. Ortiz, A. J. Grodzinsky, D. Heinegård and L. Han, “Nanomechanical phenotype of chondroadherin-null murine articular cartilage,” Matrix Biology, 38, pp. 84-90, 2014
D. J. Rubin, H. T. Nia, T. Desire, P. Nguyen, M. Gevelber, C. Ortiz and N. Joshi, “Mechanical reinforcement of polymeric fibers through peptide nanotube incorporation,” Biomacromolecules, 14(10) pp 3370–3375, 2013
H. T. Nia, L. Han, Y. Li, C. Ortiz and A. J. Grodzinsky, “Poroelasticity of cartilage at the nanoscale,” Biophysical Journal, 101(9) pp. 2304-2313, 2011
H. T. Nia, A. Jain, M. Alam, Y. Liu, R. Barnas, and N.C. Makris, “The evolution of air resonance power efficiency in the violin and its ancestors,” Royal Society Proceeding A, 2015. Featured by New York Times, Economist, USA Today, Christian Science Monitor, MIT News, NBC News
S. Jagannathan, D. Symonds, I. Bertsatos, T. Chen, M. Andrews, Z. Gong, N. Donabed, H. T. Nia, A. Tan, L. Ngor, R. Nero, M. Jech, O. R. Godo, S. Lee, P. Ratilal, and N. Makris, “Ocean Acoustic Waveguide Remote Sensing (OAWRS) of marine ecosystems,” Marine Ecology Progress Series, 395, pp. 137-160, 2009
K. Sugimoto, and H. T. Nia, “Dynamic simulator of mechanisms based on the tangent and cotangent vectors,” Journal of Robotic Society of Japan, 25(4), pp. 134-140, 2007 (In Japanese)
H. T. Nia, H. N. Pishkenari and A. Meghdari, “A recursive approach for analysis of snake robots using Kane’s equations,” Robotica, 24(2), pp. 251-256, 2006
H. Zohoor and H. T. Nia, “Optimal synthesis of planar and spatial mechanisms for path generation using regression deviation,” Scientica Iranica, 12(2), pp. 190-198, 2005